Exo-spin™ products provide a proven, rapid and reliable way of generating high quality purified exosomes suitable for a range of research applications. Blood plasma and sera typically contain around 1 x 10^12 exosomes/ml. Size exclusion chromatography (SEC), provides a superior to technique to purify exosomes from blood. Blood can be added directly onto the column or concentrated a little, if necessary, prior to application. Blood plasma has higher protein content than sera reducing the amount that can be loaded onto each column. The EX02 Exo-spin™ kit has been developed to process small volumes of blood samples (both plasma and sera). The kit includes Exo-spin™ buffer as well as SEC columns. The Exo-spin™ buffer is a polymer-based precipitation buffer which can be used for the optional first step. For the second step, pre-packed and equilibrated ready-to-use SEC columns provide reliable and consistent results.