The Seraseq®Jacobs Syndrome (XYY) Reference Material is intended for use in Whole Genome or Targeted Next Generation Sequencing (NGS) assays, dPCR, or microarray assays that screen for the sex chromosome aneuploidy 47,XYY (also known as Jacobs syndrome, XYY karyotype, XYY syndrome and YY syndrome) in cell-free DNA (cfDNA) present in maternal blood. Seraseq® Jacobs Syndrome (XYY) Reference Material is derived from DNA extracted from a pregnant patient source sample carrying a fetus with confirmed confirmed Jacobs Syndrome. This product is available in a simulated plasma matrix, enabelling the assessing the complete workflow from extraction through to analysis, similar to clinical samples. This reference material is intended for researchers and Non-Invasive Prenatal Testing (NIPT) labs to monitor library preparation, sequencing, and detection performance.