The Seraseq®Trisomy 21 Female -Matched ReferenceMaterialis formulated for use with whole genome or targeted Next Generation Sequencing (NGS) assays or microarray assays that screen for Trisomy 21 (Down Syndrome) chromosomal abnormality in cell-free fetal DNA (cfDNA). The Seraseq®Trisomy 21 Female -Matched Reference Material, created with matched (or related) maternal-fetal source material,is intended as a reference material for researchers and Non-Invasive Prenatal Testing (NIPT) labs to monitor library preparation, sequencing, and detection performance.