Heme Malignancy

The molecular analysis of heme malignancies now includes NGS as complementary technology to the traditional methods such as FISH and qPCR. NGS hematological disorder assays developed and deployed to profile patients for these malignancies provide a highly multiplexed analysis of genomic aberrations that underpin many of these diseases. Assay development, validation and clinical deployment will often require the use of clinical patient samples to aid these efforts. However, due to the vast diversity of genetic alterations in blood cancers, it can be a monumental and expensive task to source sufficient quantities of remnant patient specimens and cell lines bearing clinically relevant variants across these different diseases.

Seraseq^® Myeloid Produkte

• Seraseq Myeloid Mutation DNA Mix (0710-0408)
• Seraseq Myeloid Fusion RNA Mix (0710-0407)
• Seraseq Myeloid ctDNA Mix (0710-2646 / 0710-2647 / 0710-2648 / 0710-2649)

Diese Produkte sind mit einer Reihe von NGS-Myeloid-Assays kompatibel, z. B:

• AmpliSeq™ for Illumina Myeloid Panel
• Thermo Fisher Oncomine® Focus and Oncomine Myeloid Research Assay
• Archer® VariantPlex® and FusionPlex® Panels
• Illumina TruSight® Myeloid Sequencing Panel

Features:

• 23 DNA variants in Seraseq Myeloid Mutation DNA Mix
• 9 RNA fusions in Seraseq Myeloid Fusion RNA Mix
• 25 DNA variants in Seraseq Myeloid ctDNA Mix
• Variants precisely quantified using highly sensitive digital PCR assays, and blended with a single well-characterized genomic background
• Validated by targeted NGS panels
• Manufactured in GMP-compliant, ISO 13485-certified facilities

Productsheet

Seraseq^® Lymphoma DNA Produkte

• Seraseq Lymphoma DNA Mutation Mix (0710-2203)
• Seraseq FFPE Lymphoma DNA Reference Material (0710-2202)

 
Features:

• Designed and manufactured to support NGS assays for Lymphoma patient disease profiling
• Highly multiplexed - 26 DNA variants covering SNVs, INDELs, and SVs
• Blended against a well-characterized GM24385 WT cell line background
• VAF range between 5% to 15% based on digital PCR quantitation
•  Manufactured under cGMP and ISO 13485

Productsheet