The Seraseq® gDNA HRD High-Positive, Low-Positive and Negative Mix products contains genomic DNA (gDNA) purified from tumor and SNP-matched normal human cancer cell lines. Seraseq® gDNA HRD High-Positive, Low-Positive and Negative Mix products are reference materials designed for measuring Homologous Recombination Deficiency (HRD) status via genomic instability in cancer patient samples using targeted next generation sequencing (NGS) assays under a specific set of bioinformatics pipeline parameters. Biosynthetic variants in 4 key homologous recombination repair (HRR) genes are added to to the High-Positive (0710-2879) and Negative (0710-2881) reference materials.